Antidiarrheal Effect And Its Mechanism Of Rumex Leaf Water Extract

The antidiarrheal effects of Aqueous Extract of Rumex japonicus Houtt leaves (YT) and the mechanism involved were investigated in mis paper.The results showed that the secretory diarrhea induced by castor oil, the osmotic diarrhea induced by Na2SO4 in the mice could be remarkably inhibited by intraperitoneal(ip) YT 0.8, 0.4, 0.2g/kg and endermosis 3.0, 1.5, 0.8g/kg. The frequency of defecation was reduced and the latency of excreting black feces prolonged. Oral administrated YT(po 0.8, 0.4, 0.2g/kg) had no obvious effects on the diarrhea induced by castor oil and Na2SO4. However, YT as the references reported, has the significant cathartic and purgative effects. Above studies indicated that multi-type of diarrhea were significantly inhibited by YT administrated ip. and endermosis. In addition, the small intestinal transit in mice were delayed by ip. and endermosis. YT at the dose of 0.8, 0.4, 0.2g/kg. But oral administration didn't show the similar action. It was concluded that the effects of administration of YT by ip and endermosis is contrary to that of administration by po.The Neostigmine-induced hyperperistalsis of the small intestine was inhibited and the inhibitory effect of Atropine enhanced by ip and sc administration of YT suggesting the mechanism of YT involved the antagonism of Ach. But the contraction of isolated rabbit ileum was not inhibited by YT. The contraction of the small intestine induced by Ach in isolated rabbit was not affected by YT suggesting that YT has the antagonistic effects on the H1 receptor in the intestinal tract, and then inhibits the bellyache and secretory diarrhea induced by the contraction of the intestinal smooth muscle due to the excitation of H1 receptor, the secretion of gastric acid and gastric proteinase induced by histamine. The inhibitory action of smallintestinal transit of YT was not antagonized by pretreadng with Phentolamine or Propranolol in mice, suggesting that the michanism of YT was not related with a and b-adrenergic receptor. YT could remarkably inhibited pain response caused by acetic acid. At the same time YT suppressed the emesis in pigeon. Taken together, it is the conclusion that YT, as an anti-diarrheal drug, must achieve delightful benefits of economy and society.