| IntroductionLeptin is the product of the obesity (ob) gene. It is a protein hormone secreted maily by adipocyte and plays a important role in energy regulating system. It regulates both appetite and energy expenditure. Because of the special physical state, the results of studies with same studying target in fetus and newborns are always different from that in adults. By now, the mechanisms of leptin in regulating fetal and newborn infanta! body growth and energy metabolism are poorly understood.ObjectiveTo determine the relationship between cord blood leptin levels and fetal growth and the increase of body weight in early neonatal period. To study the effect of varies delivery method on cord blood leptin concentration and the impact of ADT ( antenal dexamethsone treatment) on cord blood leptin and cortisol level. To evaluate the function of leptin in regulating neonatal growth and development .MethodThe study population comprised 74 healthy newboms(21 are premature) ,in several cases (n =45) paired mother -fetus blood samples were obtained. All the neonates and mother with a notable diseasesuch as asphxia, inflamation, malformation, and all kind of metabolic and genetic disease were excluded. Leptin, insulin and cortisol levels were measured by RIA. Anthropometric data (birth weight,body mass Index, placenta! weight, the thick of skin fold) were recorded. The whole volum of milk in the first 48 hour of life and bodyweight at the first,the second,and the sixth month after birth are also acquired.Result1. The relationship between cord blood leptin level and anthropor metric data: There was a significant positive correlation between cord blood leptin levels and placental weight, birth weight, body mass Index (p <0. 001) ,The cord blood leptin levels matched to per BMI unite in neonate were higher than those of adults. Thogh the mean leptin level in female infant was higher than that in male infant, the difference had no statistic significance( p =0. 09) .2. The relationship between cord blood leptin and cord blood insulin level: The cord blood leptin levels were closely correlated with umbilical insulin levels in term infants( r = 0.463, p = 0.002, n = 44) , and even after accounting for the total body fat , the relation was still exist. But no same relationship was found in premature (r = -0.087, p = 0. 748, n = 16 ). The leptin levels of cord did not associate with those of the mothers.3. The relationship between cord blood leptin level and the volume of milk taken in the first 48 hours of life, and the increase of body weihgt after birth: The cord blood leptin levels were closely correlated with the volume of milk taken in the first 48 hours of life ( r =0. 731,p <0.001). In term infants ?the cord blood leptin levels werenegatively correlated with the increases of body weight at the first, the second and the sixth months age. But in premature,the leptin concentrations did not associated with the increases of body weight at any months age(p >0.05). The increases of body weight at 6 months age had no relationship to feeding method.4. The relationship between umbilical leptin concentration and the delivery method:There is difference between arterial and venous leptin levels in normal deli very (p =0. 020) ,and in cesarean section after delivery onset (p =0. 035) ,but not in elective cesarean section . The cord leptin levels associated with delivery method: The cord leptin levels of infants given birth with normal delivery and cesarean section after delivery onset were far higher than those with elective cesarean section ( p =0. 002 and 0. 021 respectively) . But there were no difference between the cord leptin levels of infants given birth with normal delivery and cesarean section after delivery onset ( p = 0. 263). The cord blood cortisol levels were also associated with delivery method : The cord blood cortisol levels are equally lower in infants given birth with elective cesarean section and cesarean section after delivery onset than those in infants given birth with... |
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