Study On The Synthesis Of Anti-influenza Virus Drugs Arbidol And Its Derivatives

The process of anti-influenza agent Arbidol was studied in this paper, the design and synthesis of its derivatives were reported as well.The development of anti-influenza agents was described in this paper. Arbidol, a new anti-influenza drug, was introduced in detail, including its antiviral mechanisms, pharmacological properties and clinical effects. The process of Arbidol was researched particularly. With 1,4-bezenoquinone and ethyl acetoacetate as the starting materials, it had been prepared in a novel six-step procedure in overall yield of 34.6%. A key step in the synthesis, the Nenitzescu reaction, was improved, its yield was increased by 10% higher than literature's.Based on the analysis of structure-activity relationships (SAR) of Arbidol analogues, seven target compounds were designed and prepared, six of them were new compounds. The structures of Arbidol and its derivatives were confirmed by IR, H-NMR, MS, TGA (to Arbidol).The pharmacological evaluation of these target compounds is in progress.