| Male Immunological Infertility iS a autoimmune disease characterized byantisperm antibodies presenc in the serum or seminal plasm．Antisperm antibodieswill leads to male infertility．This paper bases on the fact that GMK(Guo Min Kang IICapsule,a kind off Chinese medicine)has cured a lot of infertility patients,we havesummaried clinical data,and by means Of making animal model,we observe the effectof GMK on the mice model with immunological infertility． This paper iS divided into three parts:literature overview,clinical curative effect,experimental study1 Literature overview The cause of a disease male immunological infertility is the sperm or seminalplasm gets in touch with immune system,thus,antisperm antibodies OCCURS in theserum or seminal plasm．there are three kinds of antibodies includeing IgA,IgG,IgM There are several reasons for the appearance of antisperm antibodies．Antispermantibodies through below mechanisms to cause male immunological infertility:1)Antisperm antibodies have Agglutination,they will lead to sperm Coagulation 2)cytotoxic effect on spermatozoa in the presence of complement 3)antispermantibodies result in lOSS of sperm metabolism activity 4,antisperm antibodies blockcapacitation in sperm 5)inhibition of sperm penetration throngh human zonapellucida by antisperm antibodies 6)the presence of antisperm antibodies increasethe damages to spermatozoon plasma membranes 7)the fertilization rate,embryonicquality and early embryonic cleavage of human embryos was reduced significantly byantisperm antibodies．Immunosuppression therapeutics:low dose glucocorticoid treatment；high doseglucocorticoid treatment:periodic treatment,etcAssistedreproduction technology: intrauterine insemination ．In vitrofertilization,Intracytoplasmic sperm injection,subzoual inseminatio,etc Male Immunological Infertility has no name in traditional Chinese medicaine．according to its clinic manifestation,it belongs to"infertility"。traditional Chinese medicine think origins Of mis disease due to natural endowment deficiency or wet heat stasis in the body．Many Chinese traditional medicaine physicianes have仃earedthis disease with they own themry and medical herbs．They have obtained satisfactorycurative effect．2 Clinical curative effect: we used computer assist sperm analysis to evaule semen quality in order to obtain overall information．forty．two patients with immunological infertility caused by antisperm antibodies were treated with GMK,healing rate was 3 3．3 3％．Inefficient rate was 16．67％,total efficient rate was 83．33％．to compare the previous state,there were marked rises in ten semen parameters(pIn conclusion．GMK is very effective to cure male immunological infertility3 Experimental studyTo observe the effect of GMK on normal mice immune organs,sixty mice wereallocated to five groups:normal group,prednisone acetates group,high dose group,middle dose group,10w dose group,After ten days administration,calculatedspleen exponent and thymus gland exponent．the spleen exponent and thymus glandexponent of normal group are higher than other four groups,this outcome suggestedGMK could suppress normal immune organs growth． To investigate whether Chinese medicine GMK could inhibit antispermantibodies in experimental mice．the experimental immunological infertility mice wereinduced bv ini ection of human sperm membrane antigens,the experimental mice usedin the present study were divided into seven groups,inclding:normal group,adjuvantgroup,model group,prednisone acetates group,high dose group,middle dose group,lOW dose group．the enzyme．1inked immunosorbent asssy(ELISA)were used fordetection of antisperm antibodies,the change of levels o... |
