Acupuncture Rapid Aging Model Mice Samp6 Osteoporosis And Trace Elements In Experimental Research

Object: To study the effects of acupuncture on bone histomophometry and trace elements concentrations of femur and viscera of SAMP6. Methods: The femur of 3-month-old, 6-month-oId SAMP6 and SAMR1; SAMP6 after acupuncture were processed undecalcified for bone histomophometry, compared with SAMP6 without acupuncture and SAMR1. Trace elements concentrations of femur and viscera were assessed by means of atomic absorption spectroscopy in SAMP6. SAMR1 and SAMP6 after acupuncture. Results: 1. SAMP6 mice show early-onset and progressive osteoporosis, compared with SAMR1 in bone histomophometry. 2. There is a difference in trace element level and distribution between SAMP6 and SAMR1 mice. There are significantly decreased in Cu, Zn. Mg and Ca concentrations of femur; Cu and Mg concentrations of brain: Mg concentration of liver; Cu concentration of skin; Zn, Ca and Fe concentrations of blood serum in SAMP6 mice compared with SAMR1, while significantly increased in Zn and Mg concentrations of heart; Cu and Fe concentrations of lung; Cu concentrations of liver; Cu and Zn concentrations of kidney; Zn and Mg concentrations of skin; Cu and Mg concentrations of blood serum in SAMP6 mice compared with SAMR1. 3. After acupuncture "Shenshu" point, there are significantly increased in Ca, Mg and Zn concentrations of the femur, and significantly decreased in Cu concentration of serum; Fe concentration of lung in SAMP6 mice. 4. Acupuncture on "Shenshu" point can improve some bone histomophometry indexs to some degree. Conclusion: The results proved that SAMP6 mice were a novel osteoporosis animal model, which characteristic has no change since SAMP6 were introduced to China. It is successful breeding of SAMP6 in our hospital. It is possible that acupuncture has the function of regulating the level of trace element in S AMP6 mice and acupuncture maybe have a good effect on senile osteoporosis in SAMP6 mice.