Pleconaril The Synthesis Of New Antiviral Drugs

The characteristics of virus and the development of antiviral agengts were briefly described in this paper, and the mechanism of a new broad -spectrum Picomavirus Inhibitors-Pleconaril was also introduced. The synthesis of Pleconaril was studied. A new synthetic route was designed and modified, which make easier to process, and the yield was elevated. The total yield of Pleconaril was 37.4%, which was synthesized from 2,6-dimethyl-4-hydroxyphenol by ten steps, including the preparation of side chains. Its structure was confirmed by IR, 1H-NMR, ?C-NMR, MS. The polymorphs of Pleconaril was also studied in different solvents.