Paul God Gloomy Granules For Treatment Of Insomnia Interleukin -6 Impact Of Clinical Observation

Objective: The aims of this study were to evaluate curative effect of BaoshenKaiyu Chongji in treating insomnia and investigate the active mechanism of BaoshenKaiyu chongji. Methods: After three months long samples collection, forty patients were randomly sampled in 2 treatment groups, they are Diazepam control group and BaoShenKaiYu chongji treatment group. The quantity and depth of sleep were assessed by the Pittsburgh sleep quality index (PSQI)at one month interval. At the same time, the patient's plasma interleukin-6(IL-6) were measured twice at both the beginning and the end of the treatment. Then, the data was send to several statistical processes. Result: There is a significant improvement of sleep quality of patients who suffered from insomnia in two groups. But there is a difference between two groups in circadian secretion of 11-6, that is to say, before treatment, Daytime's the secretion level of IL-6 in two groups was higher than that in the night. But after treatment the daytime's level of IL-6 in Baoshenkaiyuchongji group was decreased, and the night's level was increased, and the control group has no that changes. Conclusion: This medicine has ability of ameliorating the sleep quality of the patients who suffered from insomnia. The active mechanism of BaoShenKaiYu chongji is to adjust circadian rhythm of secretion of IL-6 into normal state.