Mild Barbiturate Therapy, And Full Mechanical Ventilation For Severe Brain Injury Of Cerebral Oxygen, Glucose Metabolism

Objective To observe the influence of mild barbiturate and controlled mechanical ventilation (MB&CMV) upon severe brain injury patients' cerebral oxygen and glucose metabolism. Methods 12 patients with acute severe head injury treated with mild barbiturate (thiopental, 4mg/kg intravenous bolus, and then 1.5mg/kg·h) and controlled mechanical ventilation were studied. After and before the treatment by using a technique of jugular catherization, the changes in cerebral arteriovenous differences of oxygen and glucose content (Da-vO2 and Da-vglu) and extrating rate of oxygen and glucose(ERO2 and ERglu) were avalyzed;while the changes of intracranial pressure(ICP), cerebral perfusion pressure(CPP) and mean arterial pressure(MAP) were did. Results Da-vO2, Da-vglu, ERO2 and ERglu after MB&CMV were significanfly less than those before MB&CMV.CPP increased (P>0.05),while MAP decreased(P>0.05) Conclusion MB&CMV can remarkably decrease severe brain injury patients' cerebral oxygen and glucose metabolism.