Pancreatic Cancer Microsatellite Instability Of Clinical And Pathological Characteristics Of Study

Microsatellite InstabiIity in Pancreatic Careinomas and Its Relationship to Tumor ClinicopathologyPostgraduate: He lizhiSupervisor: Xie MingThe Research Institute of Hepatobiliary SurgeryAbstractObjective To investigate the microsatellite instability (MSI)in pancreatic carcinomas and its relationship to cancer cl inicopathology.Methods We determined the frequency of instability at 6 microsatellite loci in 41 pancreatic carcinomas using polymerase chain reaction. We then correlated the MSI status with the clinicopathological features of cancers.Results Instatility rates among 6 loci were significantly different (P=0. 0312). MSI was observed with at least one locus in thirty carcinomas (73%30/41), among these tumors, fifteen of thirty carcinomas(50%) showed two or more MSI. Pancreatic carcinomas with MSI in at least one locus were a significant higher frequency in stage I & II (100% 10/10) than that in stage III & IV (65% 20/31 P=0. 0268). MSI was no statistically significant association with age, sex, grade and location of pancreatic carcinomas.Conclusion The result suggested that the MSI may he an early event and play an important role in tumorigenesis of pancreatic carcinomas.