Adrenomedullin Levels In The Comparative Analysis Of The Aortic Root And Coronary Sinus Ministry Correlation With Cardiac Function Analysis

From June 1999 to April 2000, 27 patients were subjected to cardiac ultrasonic check up (for all the 27 patients) and left ventriculography (for 13 patients) to measure the ejective fraction (EF) respectively. During cardiac operations, the author collected the blood samplings in the Aortic Root and Coronary Sinus before Cardiopulmonary Bypass, and those samplings were determined for Adrenomedullin (AM or ADM) concentrations by radioimmunoassay technique. The AM concentrations in the Aortic Root and Coronary Sinus and EF of each patient were underwent statistic analyses by SPSS (a kind of current & universal software for the disposal of statistic data). The SPSS shows the statistic results: ① There is no significant statistic difference between concentrations of AM in Aortic Root and Coronary Sinus (p=0.200 >0.05); ②AM concentrations in the Aortic Root and Coronary Sinus are correlated significantly & positively in statistic senses (r=0.805, p<0.01); ③AM concentrations in the Aortic Root and EF are correlated significantly & negatively in statistic senses (r=-0.781, p<0.01); ④AM concentrations in the Coronary Sinus and EF are correlated significantly & negatively in statistic senses (r=-0.667, p<0.01). The author offers explains: ①The heart dose not compound or secrete, and dose not utilize or metabolize AM either; ②The heart compounds, but dose not secrete, or just autocrines or paracrines AM; ③The heart not only compounds and secretes but also utilizes and metabolizes AM. However, the quantities are tantamount; ④The heart does secrete AM into the blood circulation, but the quantity is so inappreciable, contrasting to the gross AM in the plasma, that there is no significant statistic difference between concentrations of AM in Aortic Root and Coronary Sinus. In addition, plasma AM concentrations are heightened markedly in heart failure, and is correlated significantly and positively with the degree of it. AM acts as a protective factor in heart failure, and it shall be recommended for future wilder clinical use.