Huang Hepatitis B Capsule Anti-hepatitis B Virus In Serum Pharmacology,

Viral hepatitis B is a common infectious disease with the main features of the inflanimatoin of the liver, and the degeneration and necrosis of the hepatocyte. The disease has high mobidity with secret invasion and long course of disease, and it inclines to convert to hepatocirrhosis and primary hepatoma. Hepatitis B virus (HBV) is the most direct pathogenic factor of the viral hepatitis B. I-LBV is a kind of hepadna virus with strong pathogenicity, high mutation and powerful resistance, and it has been greatly threatening the human health and lives nowadays. San Huang ~?Gan Capsule (Sl-IYGC) consists of Huang Qin~ Da Huang~ Chai Hu~ Huang Qi~ Wu Wei Zi.. Gan Cao with the efficiency of clearing away heat-evil and wetness-evil, dispersing the stagnated liver-energy and invigorating the spleen. After having been used clinically for many years, it was found to have significant therapeutic effectiveness on the acute and chronic viral hepatitis B in the type of the retention of dampness-heat in the interior, the stagnation of the liver-qi and the deficiency of the spleen. In order to explore the mechanism of the effectiveness deeply, we canied the study of SHYGC against I-IBV with the seropharrnacological method. The results of the experiment indicate that: (1) SHYGC has significant inhibitory effects on HBsAg. The inhibitory effects on HBsAg of the rabbit sera containing SHYGC become stronger with the dosage improved and the action time prolonged, and they decrease with the l-IBsAg concentration improved. The inhibitory effect on HBsAg of the serum containing hing- dose SHYGC is stronger than that of the serum containing ACV, and is equal to that of Su Xiao Jing containing 2SOPPM available chloiic. The direct external inhibitoiy effects of SHYCIC in original pharmaceutics are more powerful, even stronger than the sera containing SHYGC. (2) SHYGC has significant inhibitory effects on HBeAg. The inhibitory effects on HBeAg of the rabbit sera containing SHYGC become stronger with the dosage 3 improved and die action time prolonged, and they decrease with the HBeAg concentration iniprovecL The inhibitory effect on HBeAg of the senmi containing hing- dose SHYGC is stronger than that of the senmi containing AC~ and is equal to that of Su Xiao Jing containing 25OPPM available chloric. 711ie direct external inhibitory effects of SHYGC in original pharmaceutics are more po~iful, even stronger than the scm containing SHYGC. It probably indicates that the active ingr~1ients of S1-IYGC can not be digested and absorbed completely from gastmintestine, or are inactived by metabolism in vivo. (3) The rabbit scm containing SIIYGC have significant inhibitory effects on HBV DNA polymerases (l-LBV DNAP), and they become stronger with the dosage bnprovecL There is no distinct difference bet~en the inhibitory effect on I-LBV DNAP of the sen.nn containing hing-dose SHYGC and that of the sen~m containing ACV (4) The rabbit sen.tm containing hing-dose SHYGC has significant inhibitory effects on HBV DNA, wi抰ich is equal to that of the serum containing ACV and Su Xiao Jing containing 25OPPM available chloric. Chinese herbal serophaimacology has been a new external testing method of Chinese herbal pharmacology in recent ten yeazs. The method is to sample the blood of the animal ~&4iich have been orally administered Chinese herbs or Chinese heital compl...