| Purpose:Realve the rule of PMS syndrome differentiation and medicine usage, through analyzing the last 20 years clinical documents about PMS treatment, and the reasults searched by Puji Fang data base management system. Consequently, make a prescription focusing on PMS treatment, which is empirical studied and confirmed. Establish a kind of thought and method in screening a smal effective TCM prescription on PMS regulation.Material and method:1. Inductive statistics the syndrome differentiation and medicine usage, through searching the last 20 years TCM clinical documents on CNKI, CQWP, CBM periodical data base.2. Statistical analysis the reasult about ancient medicine usage, searchend from Puji Fang data base management system.3. Apply the methods of hot plat and reduce streching to observe analgestic effect4. Apply the test of spontaneous movement and joint action with subthreshold dose of pentobarbital sodium to observe the sedation5. Establish hight ESG section of PMS animal models through injecting estradiol benzoate to investigate the ESG regulating effect.Result:1. There are many major differences or contradiction of PMS syndrome differentiation in authority standards, academic circles, and between authority and academic circles.2. The medicine usage in ancient and modern years concentrates on the ones with effect of menstrual regulation, qi regulation and tonification.3. YQS can raise the pain threshold on hot plat and reduce streching times4. YQS can inhibit spontaneous movement, and increase spleep mice numbers;5. YQS can lower rats'serum E2 content. Conclusion:1. PMS is characterized by liver-qi stagnation and spleen deficiency.2. YQS has the effect of analgesia, mitigation, and lower the E2 contained in serum, which is hopefully applied on clinical usage to relieve PMS.3. The screening thought: document researchâ†'identification of indicationâ†'state base combined with clinical treatmentâ†'empirical study and confirm, is convenient and pragmatic. |
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