Fosinopril Synthesis

The mechanism,developing,recent advances,clinical application and market outlook of the angiotensin-converting enzyme inhibitor are briefly reviewed in this thesis.We introduced Fosinopril specially,which is one of the representatives of the third generation ACE inhibitors,evaluated and studied its synthetic process in detail,evaluated and studied its synthetic process in detail.Fosinopril can be prepared through condensation by PC-7 and PA-7. Fosinopril is identified by MS, NMR and physical property. The work will be much helpful to approach industrial production of Fosinopril and synthesis of the Fosinopril analogues.