Metastatic Liver Cancer Hepatic Arteriography Blood For Analysis And Interventional Therapy Observed

ObjectiveTo evaluate the blood supply of metastases of liver by using hepatic artery angiography andTo discuss the efficacy and modality of intervention therpy in patients with metastatic livercancer.Method1. Forty two patients [male 28,female 14,average age (52.5±14.3)y]with metastases ofliver from Sep 2008 to Mar 2011 in our hospital were enrolled in this study . Among them ,14cases had intestinal cancer, 5 cases with primary gastric cancer ,8 cases pancreatic cancer ,8cases lung cancer and 7 cases with other kinds of cancer . forty two patients totally had 105metastaic lesions [mean diameter (3.2±1.2)cm].2. Hepatic artery angiography was performed in all cases ,portal vein angiography indirectlytoo. the hepatic arterial blood supply of the metastases of liver was assessed according to thepathologic type ,the volume of metastases and sites.3.According to the blood supply patterns of the metastatic lesions, all patients receiveddifferent modalities of the intervention therapy ,among them ,20 patients with rich blood supplyand 9 patients with middle blood supply were undergone intrahepatic artery chemoembolizationand transcatheter infusion chemotherapy by using the newest chemotherapy method, while 13patients with poor blood supply were undergone transcatheter infusion chemotherapy by usingthe newest chemotherapy method. The catheters were inserted by using Seldinger technique andretained for ending of chemotherapy.an interval of 21-28 days .All cases were cured for fourtimes.After intervention therapy ,the clinical manifestation and survival time were observed andanalyzed for each case after two times.Result1. The distribution of 105 nodules in 42 cases in the liver had no stastistically significans .seventy two in 105 nodules (68.8%) were hypervascular or moderate blood supply . without anytumor stain apacified from the portal vein angiography indirectly ,except the peripheral vegion oftumor even none. The blood supply of hepatic artery to the metastases showed no correlationwith the size of metastases ,but to the pathologic type of the neoplasm.2.The follow-up demonstrated that ,the main symptoms and signs in all patients wererelieved to different extent . there were severe complications related to the procedure. Thesurvival rate of the patients at 6,12 and 24 months after intervention therapy was 96.8%,61.3%and 42.3%, respectively. ConclusioConclusion1. Hepatic artery is the major feeding vessel to the metastases of liver ,but those in theperipheral region of the liver may receive some from the portal vein angiography or even none.2. Intervention therapy selecting proper modality based on the blood supply pattern of themetastatic lesions for unresectable liver metastases may obtain more satisfactory efficacy.3. Arsenic trioxide can constrain the hepatic cell from many factors. It is safety andefficacy for many patients of liver metastases.