Research On The Changes And Value Of The Serum Myocardial Enzymes And Troponin â… (ctni) In Neonates With Hypoxic Pulmonary Hypertension

Objective: To study the changes and clinical value of the serum myocardial enzymes and cardial troponin I (cTnI) in neonates with hypoxic pulmonary hypertension (HPH). Methods: there were totally 30 cases of neonates as HPH group and 30 cases of neonates as control group enrolled. Tests were performed on on the 1st and 7th day after birth separately, which include the level of serum myocardial enzymes and cTnI, pulmonary artery systolic pressure(PASP) by using the color Doppler echocardiography and blood gas analysis by the femoral arterial blood at the same time. Results: 1. There are significant differences (P<0.05) of the values of PaO₂, PASP between the HPH group and the control group on the 1st day, while there are no significant difference (P>0.05) on the 7th day. There is a negative relation between the PaO₂ and PASP(P<0.05)on the 1st day in the HPH groups, but there is no relation between PaO₂ and PASP(P>0.05)on the 7th day in the HPH groups. 2. The level of serum myocardial enzymes and cTnI obviously increase and have a significant difference in the HPH groups between the control group (P<0.05) on the 1st day, however, the result has no significance statistically on the 7th day. The values of creatine kinase myocardial myoglobin isoenzyme (CK-MB) and cTnI have significant difference (P<0.05) on the 1st day in the HPH group. It has a positive relation among the level of serum creatine kinase myocardial myoglobin isoenzyme, cTnI and PASP(P<0.05), but it has no relation among the level of blood serum myocardial enzymes,cTnI and PASP(P>0.05)on the 7th day between the HPH group and the control group. Conclusion: Hypoxic pulmonary hypertension can result in myocardial damage in the neonates, and the level of myocardial enzymes and cardial troponin-I will increase when myocardium are damaged. They are correlative with PaO₂ and PASP.With the improvement of hypoxia and decrease of PASP, the level of blood serum myocardial enzymes and cTnI will also decrease. So the level of blood serum myocardial enzymes and cTnI can reflect the myocardial damage in the neonatal hypoxic pulmonary hypertension, they provide an evidence for early diagnosis and treatment of the myocardial damage in the neonatal hypoxic pulmonary hypertension.