Expression Characteristic And Correlation Of Fak And Epha2 In Human Gliomas

Object: To explore the expression of FAK and EphA2 in various grade of human gliomas and their correlation,to explain the role of FAK and EphA2 in the tumorigenesis and progression of human gliomas.Methods: 65 of primary human gliomas were collected,including 38 of gradeⅠ-Ⅱ(low potential malignancy),27 of gradeⅢ-Ⅳ(high potential malignancy). Male 34 cases and female 31 cases age are from 4 to 72 years old .all the cases didn't accept radio-or chemical-therapy before surgery; 14 of normal fresh cerebral tissuses were used to compare. The expression of FAKprotein and EphA2 protein were detected by SP immunohistochemistry,and the correlation was analyzed.Results:the immunohistochemistry results exhibited: EphA2 protein was detected in primary human gliomas but not in normal cerebral tissuses.the EphA2 protein in high potential malignancy was considerably higher than that in low potential malignancy(P<0.05). FAK protein was detected in both primary human gliomas and normal cerebral tissuses. The level of FAK protein in high and low potential malignancy was respectively considerably higher than that of in normal cerebral tissuses(P<0.05). The level of FAK protein in high potential malignancy was considerably higher than that of in low potential malignancy(P<0.05).The expression of FAK and EphA2 in glioma had no relationship with sex﹑age﹑diameter of tumor. (P>0.05),the expression of FAK and EphA2 in glioma shows positive relationship(P<0.05).Conclusions:FAK is related with the malignancy of the huaman gliomas, FAK was added accompanying with the increasing malignancy of the human gliomas;EphA2 is related with the malignancy of the huaman gliomas, EphA2 was added accompanying with the increasing malignancy of the human gliomas ;expression of the FAK and EphA2 in glioma have the obvious postive relativity,express the both distinguish each from rise the function at the same time,be in conjunction with the fuction,thus and together promote the occurrence of glioma and its growth.pass to experiment we think the high expression of FAK and EphA2 protein has something to do with the occurrence of the glioma and its biology behavior change,and can be the tumor invasivation biology index sign.The targeting theatment to FAK and EphA2 may be one of the efficient means for glioma.