Systematic Review Of Metformin In Treating Polycystic Ovary Syndrome

Purpose:To make the systematic review of "combinded treatment of clomiphene and metformin" in treating Polycystic ovary syndrome so that clinical treating decision can be made based on objective believable evaluation of the treatment to Polycystic ovary syndrome by the method, put forward the existent problem in the clinical research, draw up the methods to solve them.Method:All the randomized controlled trails about the research work of combinded treatment of metformin and clomiphene in treating Polycystic ovary syndrome in China were searched based on the methods of evidence-based medicine. All the articles were evaluated based on reliability classification, concealment of research allocation and JADAD scale review.Articles were analysised with Revman4.2 sofeware.Result:The ovulation rates and pregnancy rates of the group of combined treatment of metformin and clomiphene have conspicuous significance when compared with the clomiphene group (P<0.00001, P<0.00001)The ovulation rates and pregnancy rates of the group of combined treatment of metformin and clomiphene are conspicuous precede to the metformin group (P=00009<0.05, P=0.02<0.05).The therapeutic effect of the treatment method of combined metformin and clomiphene indicated for PCOS is ascertain, which provides the theory evidence for guiding the usage of medicine clinically. Asymmetry showed in "Funel Plot" may be related to the publication bias and the design of clinical experiment.Conclusion:Polycystic ovary syndrome in metformin and clomiphene is an efficical method.Because of the general poor methodological quality and potential publication bias,the efficacy and safety of metformin and clomiphene in the treatment of polycystic ovary syndrome should be evaluated by more rigorously designed, randmized, multiply-center trails.