The Efficacy Compare Between Psychosurgery And Drug Therapy In Refractory Schizophrenia

Objective To compare the efficacy of psychosurgery and pharmacotherapy on refractory schizophrenia. To estimate the value of the stereotactic neurosurgery in improving the psychotic symptons. restoring social function. reducing the amount of maintance treatment and making progress of quality or life.Methods 47 cases of refractory schizophrenia treated with psychosurgery in 2005-2008 were selected to make a study group and another 47 cases of refractory schizophrenia treated with drug meeting some certain conditions were picked out to make a pair of the former cases one by one to be a control group. Then make a follow-up table to collect imformation of two groups about demographics, Clinical datas. Adverse events, of course also including some relevant imformations by using even special assessment tool such SDSS(Social Disability Screening Schedule). BPRS (Brief Psychiatric Rating Scale). LQS (Life Quality Scale) and etc. All of the doctors participating the following-up plan were trained same. They have considerable experience. Then they complete the investigation and filling. All of the collecting dates were input into the statistical software of SPSS 17.0. finally analysis the results of two groups about discussing factors such as psychiatric symptoms. restoring social function. the amount of maintance dose. the quality or life and clinic adverse reactions.Results1.Compared with non- psychosurgery,the psychosurgery was obviously improved in social adaptive, the study group's score of SDSS is 6.13±5.33, lower than the Cotronl's 16.44±4.15. P=0.00002.in the amount of maintance dose:in the last month, the Case's maintance dose of major antipsychotics converted into Chlorpromazine is 98.44±84.81 lower than the control's 292.11±111.18, in the most recent year, the Case's maintance dose of major antipsychotics converted into Chlorpromazine is 99.56±84.12, lower than the control's 294.00±18.10, P=0.0000;3.in proving the quality or life, the Case's scores of LQS (Life Quality Scale)is 3.2±1.18, higher than the Control group 2.76±0.74, p=0.044。4.in improving the psychotic symptons, stereotactic neurosurgery, the scorers of case group and control group are followed 38.53±12.86,36.96±13.28, have no different. p=0.5115.As the Long-term incidence of adverse reactions is concerned, the incidence of adverse events of case group and control group are followedl0.6%,13.3%, have no different. p=0.552ConclusionsTo cure the Refractory Schizophrenia, the psychosurgery of stereotactic neurosurgery is one of the effective methods. In particular,to improve the psychotic symptons,restore social function.reduce the amount of maintance dose,make progress of quality or life, and less the long-term Surgical adverse events. In improving the psychotic symptons, the psychosurgery have considerable effect as the no- psychosurgery.