Preliminary Study Of The Renal Safety Film Preparation Process And Quality Standards

Shen An. Tablet is a compond preparation developed according to a prescription,which had been tested in clinic.It consists of Epinmendium ,Astragalus and Rhubarb. Shen An Pian is beneficial for treating chronic renal failure(CRF) and has the effect of invigorating spleen and kidney.The author has studied on its preparation process and quality standards.1.Research ReviewSummarizing that Etiology and Pathogenesis of CRF, therapeutic thoughts and methods of chinese medicine for CRF and Modern pharmacological study. In addition I also study other aspects of drug's main chemical components and Pharmacological.2.Study on the preparationIn accordance with properties of the herbs of the prescription and the need in theclinic, the tablets were selected as the dosage form of the drug. To optimize theextraction by several orthogonal tests. Using the content of Icariin and Astragaloside as indexes,the optimum extracting condition with Semi-bionic Design was made,that was extracting 3 times, a total of five hours. Adding water, followed by 12 times,10 times,8 times for the most appropriate and the PH value of each order of the extracted followed by2,7,9。Using the content of free anthraquinones as indexes,the optimum extracting condition with Orthogonal water extraction process was made, that was extracting 3 times for 20 minuts per time, the PH value of water is 5.1 and the Boiling temperature is 100℃。3. Study on quality standardEpimedium and Astragalus were indentified by TLC. Thespot develops were fairly clear, and the blank test showed nointerference. Using HPLC to determine Icariin content, and the reach of method was carried out.