Part Of The Superparamagnetic Nanoparticles (co, The Mnfe <sub> 2 </ Sub> The O <sub> 4 </ Sub>) Synthesis, Characterization On Mri Applications

Magnetic resonance (MR) imaging is currently one of the most powerful in vivo imaging technologies due to its noninvasive property and multidimensional tomographic capabilities coupled with high spatial resolution. And it is a new method of tomography after CT and B imaging. And With the help of efficient imaging contrast agents, it is possible to provide the higher contrast and obtain the information-rich images for disease detection. Several types of Superparamagnetic contrast agent have been proposed for use as contrast-enhancing agent in MRI. In particular, Superparamagnetic nano-ferrites have been major focus of research due to its high saturation susceptibility. To get the MRI contrast agent being appropriate for biological application, Peoples have developed many synthetic methods such as coprecipitation and high-temperature decomposition, as well as variety of surface modification methods. However, researching a simple economical method to get a high relaxation rate and good biocompatibility MRI contrast agent has been a challenging topic.This paper is mainly about the synthesis and biological application as MRI contrast agent of Superparamagnetic nanoparticles (Co, MnFe2O4). The paper is divided into four parts: (1) It was given a brief review of the research progress in magnetic nanoparticles and MRI contrast agent. (2) It was given the synthesis of water soluble Super-paramagnetic Co nanoparticles via thetemplate of dendrimers with a trimesyl core, and preliminary study of its properties. (3) It was given the methods of the synthesis of water soluble Superparamagnetic MnFe2O4 nanoparticles. One is high-temperature decomposition based on dendrimer as a template agent, and extensive characterizations of the fabricated nanocomposites have been performed to prove it is an excellent T2 MRI contrast agent. Another is a thermal decomposition approach to the synthesis of water soluble superparamagnetic manganese ferrite (MnFe2O4) nanoparticles (NPs) for magnetic resonance (MR) imaging applications. In this approach, tetraethylene glycol was utilized as a coordination and stabilization agent, rendering the NPs water-soluble and stable. In vitro cytotoxicity test revealed that the MnFe2O4 NPs were biocompatible at a particle concentration below 200 mg/mL. The transverse relaxivity of MnFe2O4 NPs in water and cells after incubation were determined to be 189.3 mM -1 s-1 and 36.8 mM-1 s-1 based on iron concentration, respectively. In vivo MR imaging studies in conjunction with inductively coupled plasma-atomic emission spectroscopy showed that the MnFe2O4 NPs were preferentially accumulated in liver after intravenous injection for 4 h. This suggests that the developed MnFe2O4 NPs can serve as a sensitive MR imaging contrast agent for liver imaging.