Lc-ms Quickly Determine Trace Elements In Bulk Drugs And Mass Spectrometry Of Glycoluril Derivatives

By virtue of its superior performances in sensitivity and selectivity, mass spectrometry (MS) has been increasingly applied for pharmaceutical research. The capability of MS to perform on-line compositional and structural analyses through the use of hyphenated techniques such as LC/MS, MS/MS provides rich structural information, which has become one of the most powerful and ideal techniques for pharmaceutical analysis and for quality control of drug manufacturing. In this thesis, we successfully developed electrospray ionization tandem mass spectrometry coupled with high-performance liquid chromatography to analyse trace-level ingredients in bulk drugs of Citalopram and Seroquel: Five impurities in bulk drug of Citalopram were analyzed, and one structure of the novel compound of the impurities was characterized; The fragmentation mechanism of Seroquel and four related compounds were investigated, and one structure of a novel trace-level impurity in bulk drug of Seroquel was identified.In addition, the fragmentation patterns of two kinds of glycoluril derivatives has been investigated: A diagnostical fragment ion from several pairs of glycoluril derivative's positional isomers was found, by which these positional isomers can be easily distinguished; Solvation of some special fragment ions produced by protonated glycoluril derivatives was found.