Amino Benzophenone Derivatives Synthesis And Characterization

Aminobenzophenones and its derivatives as inti-inflammatory medicine haveabsolutely advantages compared with traditional in medicine. In abroad, the effect ofAminobenzophenone derivatives in medicine had been reported, however, theinvestigation on the synthesis about it is scarce. Therefore, it's important to study theoptimum reaction conditions and synthesis of Aminobenzophenone derivatives.A final medicine intermediate 4-(2-Amiophenvlamino)-4'-chlorobenzophenonewas synthesized firstly using chlorobenzene and 4-nitrobenzoyl chloride by thepreparing of 4-nitro-4'-chlorobenzphenone, 4-amino-4'-chlorobenzphenone throughNitro-reduction, 4-(2-Nitrophenvlamino)-4'-chlorobenzophenone and4-(2-Amiophenvlamino)-4'-chlorobenzophenone.The structure of the products were characterized by IR and ~1HNMR. Effect of thereaction temperature, reaction time, reactants ratio and choice of catalyst on thereaction was investigated through orthogonal experiments and single variableexperiments. The reaction steps of 4-(2-Amiophenvlamino)-4'-chlorobenzophenonewere studied systemly. The optimum reaction conditions were determinated.