A New Ring Adjacent Ketone Synthesis Method

A facile and novel synthetic route of cyclic vicinal triketones was first discovered. 4-hydroxy-quinolones and indandione were respectively dissolved in methanol in thepresence of potassium hydroxide as the base at room temperature to give the oxidative intermediates, followed by the hydrolysis under heating condition in the mixture of tetrahydrofuran and hydrochloric acid to afford the corresponding vicinal triketones as the desired products.The synthetic process of 4-hydroxy-quinolones and indandione through iodobenzene diacetate oxidation was researched. The reaction parameters such as reaction temperature, the quantity of reaction substrate and reaction time were optimized, an intermediate were obtained. TLC, ~1H-NMR and MS of the intermediates were obtained.The synthetic process of the intermediates hydrolyzing by hydrochloric acid was investigated. The reaction parameters such as reaction temperature and reaction time were optimized. TLC, ~1H-NMR and MS of the products were obtained.