Metformin Hydrochloride Sustained Release Capsules

In this thesis, Metformin Hydrochloride pellets and sustained-release pellets were prepared by powder coating technology. The preparation methods for pellets and influence factors involved stability were studied completely and thoroughly. Results show that the sustained-release pellets had good appearance and stability, the sustained-release property of pellets was marked.Ultraviolet spetrophotometry method was developed for assaying content and drug release of Metformin Hydrochloride. The method was monitored by methodology. It was simple, accurate to be used in vitro. High performance liquid chromatography method was developed to determine content of impurity in sustained-release pellets.The fit factors method was used in this thesis to study the stability of sustained-release capsule. The drug content was stable under high temperature, high humidity and intensive light tests.