Cephalosporins Cephalosporin Card Product Esters

Cefcapene pivoxil, which CAS name is5-thia-1 -azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(Aminocarbonyl)oxy]methyl-7-[[(2Z)-2-(2-amino-4-thiazolyl)-1 -ox o-2-pentenyl]amino-8-oxo,(2,2-dimethyl-1 -oxopropoxy)methyl ester,[6R-[6α,7p(Z)]]-, is chlomethyl pivalate of cefcapene(sl006),is a product of by Shionogi company,It is the cephalosporanic antibiotics of the forthly era which can be taken orally.Its research of pharmacology indicate that its active of antibacterial is stronger and dosage is smaller than other in existence cephalosporanic antibiotics which is be taken orally.So the exploitation of cefcapene pivoxil will bring preferable benefit of economy and society. This paper's work as follows: The synthesis of the cefcapene pivoxilComparing with four synthetic methods, the paper experimented more methods to synthesize the compound,the methods were bettermented continually in the course of repeating the literature's methods.Finally, a simple method was employed to prepare the left moiety:Firstly,the reaction of 4-chloroacetoacetic esters with thioureas,Secondly,the obtained 2-(2-aminothiazol-4-yl)-acetic acid esters reacted with (BOC)₂O by dichloromethene at room temperature,and...