Sulfone Cyclophane And Heterocyclic Ferrocene Sulfonyl Synthesis, Modification, Biological Activity

Enzyme catalysia simulation is rich in a challenge scitific research, which arouse the curiosity of chemist especially bio-organic chemist. Azaparacyclophane is a new kind of compound which is found in the study of artificial simulation. It can also act as host compound in the host-guest chemistry. As artificial enzymes, using hydrophobic cavities, they can capture different organic molecule to form the host-guest system, based on the difference of the ring site, size and interaction. Azaparacyclophane play a significant role in the simulation of enzyme function in some organic reaction system to mimic the binding of substrates and catalyze the reaction, consequently control the reaction specially and increase the reaction velocity. By changing the ring site and size or modifying the cyclophane with the active unit, we can design the novel active center with coordinated inclusion and multirecognition to get the special host, which would form the supramolecular system with the guest and actualize the molecular recognition and the simulation of enzyme function. In the part 1, a brief introduction of the research progress of supramolecule chemistry, cyclophane. azaparacyclophane and ferrocenophane is provided. In the part 2, a never reported kind of azaparacyclophane: 1,6,20,25-tetraaza[6.1.6.1] paracyclophane-13,32-disulfone is synthesized and decorated with ferrocenesulfonyl chloride. The application of ferrocene and its derivatives have been attracted more and more attentions in many domains, especially have been widely used in the fields of medicine, biochemistry, fuel and catalyzer. In the part 3, nitrogen heterocycles indole, morpholine, imidazole, 1,2,3,-benzotriazole, piperazine six hydrate, benzimidazole derivatives is designed to react with ferrocenesulfonyl chloride respectively and eleven new nitrogen heterocyclic ferrocenesulfonyl derivatives are synthesized from ferrocenesulfonyl chloride and the nitrogen heterocycles, confirmed by IR, ~1H NMR and Elemental analysis.In the part 4, the crystal structure of one novel midst system, which was gotten in the synthesis of fluorescene material and had never been reported is presented.