Carboxypeptidase A Inhibitor - 2 - Benzyl-5 - Bromo - 4 - Synthesis And Resolution Of The Ala

In this paper, 2-benzyl-5-bromo-4-oxo-pentanoic(A), 2-benzyl- 3-bromo- 4- oxo-pentanoic(B), a -benzyl-2-furanacetic acid(C), a -benzyl- 5-nitro- 2- furanacetic acid(D), a -benzyl-5-amino-2-furanacetic acid(E), 2-benzyl-3- hydroxylbutanoic acid(F), 2-benzyl-3-mercaptolbutanoic acid(G), 2-benzyl-3-iodobutanoic acid(H), a , a-dihydroxymethyl benzenepropanoic acid (I) were designed on the bases of the predecessors' researchment on Carboxypeptidase A and its inhibitors. The compound A was synthesized and resolutioned. The compound F was synthesized by reduction of the compound Ethyl a -benzyl-acetoacetate using Sodium Dithionite.At the same time , the synthsis of the seven compounds B,C,D,E,G,H and I was carried on and explored.