Magnetic Drug Carrier Preparation Of Crosslinked Starch Blank Ball And Biodegradability

As a drug carrier, study on nanometer magnetic crosslink starch sphere was reported in this paper as follows:Firstly, a research of preparation of crosslink starch sphere had been conducted. Based on orthogonal design, crosslink starch sphere was synthesized whose mean diameter varied from micron to nanometer in inverse microemulsion through controlling reaction conditions. Also, we found a polynomial regression equation which could prognosticate the diameter of crosslink starch by multiple linear regression.Secondly, it was studied in particular on structure and property of crosslink starch with FTIR, SEM and HNMR analysis. It was found that property of crosslink starch was very sensitive to its crosslink degree. In FTIR, around 3400cm-1?1640cm-1?1600 cm-1?from 1250cm-1 to 1269cm-1 and the ratio between 1047cm-1 and 1022 cm-1 were varied with crosslink degree changed. Meanwhile, dissolving and bibulous performance were also changed with crosslink degree. High crosslink starch nearly didn't dissolve in boiled water and could sop up more water. It was believed that substantially crosslink reaction substituted hydrogen bond for crosslink bond continually.In order to observe the degradation performance of crosslink starch sphere, we designed a reaction with glucose amylase. The result of study indicated that crosslink starch with crosslink degree 6 had the best degradation performance in comparison with 0, 2, 12, 20.Finally, magnetic crosslink starch was synthesized in situ. The particle size of it was around 60nm, density 1.37g/cm , specific surface area 73.0m2/g. Crosslink starch and ferrite were linked with chemical bond. The exist of such chemical bond had some effect on degradation performance of magnetic crosslink starch, that is, not as good as crosslink starch. The nucleus-form process of magnetic cross-linked starch microsphere was deduced on thermodynamics.