Sugar Fan Synthetic Exploratory Study

In the article, tosylation, tritylation, chlorolation,acylation were adopted to protect the hydroxy groups in saccharides selectively, cyclization to glycophanes were studied at the same time.Four ramification of a -D-methylglucoside were prepared with the method of protecting the primary hydroxy in methylglucoside, trityl groups on 6-hydroxy groups was elimilated with a mild method.the method was simplified and the yields were improved.In the series experiments, five kinds of glucosides were prepared by glycosylation and deacetylation with glucose as raw materals, two glycophane intermidiates never reported were prepared by protecting the hydroxy groups in the 1,4-di-glycoside-benzene, the two glycophane intermediate were characterized by 1H-NMR, MS and IR.Ramification of a-D-methylglucoside were adopted as model compounds to study the cyclization experiment which refer to the operation of the preparation of Crown-ether..