Synthesis Of Cyclic Beta-amino Acids Cispentacin

Annular β amino acid cispentacin is a kind of antifungalantibiotic. It ;s an important pharmaceutical intermediate in the synthesization of many Pharmaceuticals. After consulting many literatures , we chose the following way to synthesize cispentacin :diastereoselective reductive amination of 2-oxo-cyclopentanecarboxylate with a -methylbenzylamine.This method reported by Palmieri utilizes inexpensive and readily available starting materials .The only drawback of this method is the necessity of a chromatographic purification to isolate the desired diastereomer .This thesis also reports some research work on the synthesization of di-Et adipate and gets the conclusion of the most reasonable time,the best proportion of acid and alcohol,the most reasonable quality of catalyzer in this.chemical reaction.And also synthesizes the a-methylbenzylamineand 2-oxo-cyclopentanecarboxylate,,...