Compound Qingyin Film Technology And Quality Standards For Research

Compound QingYin tablet consisits of Chinese herb Folium Isatidis, Flos Lonicerae, Radix Sophorae Tonkinensis, and chemical medicine Paracetamol, Chlorphenamne Maleate, Vitamin C, etc. It is applied mainly to treat rheum and rheum epidemic. The preparation process of this product were screened, the quality standard was established and the preliminary stability was investigated. The test of quality and the basic stability of three batchs of tablets have showed that the production technique was reasonable and practical, the quality was controllable, and the quality of the end product was stable.In the study of the preparation process, the optimum water extracting condition of the Chinese herb was selected by orthogonal experiment. Then we have explored the best conditions of the purification, extration and concentration methods by single-factor experiment. Contrast experiment was carried out on the adjuvant and the manufacturing process of tablets. According to the experiment results and the characters of the components in the preparation, we can determine the type and dosage of adjuvant, also the manufacturing process was ascertained.The quality standard established the thin chromatography identifiction of Folium Isatidis, Radix Sophorae Tonkinensis , Paracetamol. Chlorphenamne Maleate, Vitamin C, and every checks all meets the standard of the pharmacopeia. The content of Chlorogenic Acid, Paracetamol, Vitamin C in the preparation were measured by High performance liquid chromatography. The studies showed that these methods were sufficiently simple, sensetive and reproducible.Stability studies of three batchs of tablets demonstrated the every checks all meets the standard of the pharmacopeia, and the end product was stable.