Synthesis And Application Of ¦Â-cyclodextrin Derivatives

The main works of the thesis are as follows:1. The development of P -cyclodextrin derivatives in chromatographic analysis was reviewed. Those chromatographic techniques included gas chromatograph,high performance liquid chromatography and capillary electrophoresis.2. Four series of P -cyclodextrin derivaties were synthesizrd and confirmed. (l)Five alkylated P -cyclodextrins were synthesized included:Heptakis (2,3,6-tri-O-methyl)- 3 -CD,Heptakis (2,3,6-tri-O-ethyl)- P - CD,Haptakis (2,3,6-tri-O-butyl)- P - CD,Heptakis (2,3,6-tri-O-octyl)- P - CD,Heptakis (2,6-di-O-methyl)- P - CD.The peralkylated P - CDs were synthesized by single-step procedure.(2) Two kinds of water-soluble P -cyclodextrin derivatives were Sulfonate P -CD and Heptakis (2,6-carboxyl)- P -CD .(3) Eight P -cyclodextrin derivatives which were derivated with amino acids were:Mono-O-(N-benzoyl-DL-lactamyl)- P -CD, Mono-O-(N-benzoyl-DL- valineyl)- P -CD,3-mono-O-(N-benzoyl-DL-glycineyl)-heptakis(2,6-di-O-methyl)- P - CD, 3-mono-O-(N-benzoyl-DL-lactamyl)-heptakis(2,6-di-O-methyl)- P - CD, 3-mono-O-(N-benzoyl-DL-valineyl)-heptakis(2,6-di-O-methyl)- P - CD, 3-mono-O-(N-benzoyl-L-lactamyl)-heptakis(2,6-di-O-methyl)- P - CD, 3-mono-O-(N-benzoyl-L-valineyl)-heptakis(2,6-di-O-methyl)- P - CD, 3-mono-O-(N-benzoyl-DL- a -amino-butyl)-heptakis(2,6-di-O-methyl)- P -CD(4) Five kinds of briadged and polymerized P -CD derivatives included: Oxalyl choride polymerized P -CD,Oxalyl methyl choride polymerized 3 -CD, Oxalyl choride briadged heptakis(2,6-di-O-methyl)- 3 -CD, Tolylene 2,6-diisocyanate polymerized 3 -CD, Tolylene 2,6-diisocyanate briadged heptakis(2,6-di-O-methyl)- 3 -CD. S.Chromatographic character of 3 - CD derivatives were studied.