The Introduction Of Benzo Nitrogen-containing Heterocyclic Pyrimidine And Imidazole Derivatives

In the research and exploitation of medicine and pestcide, hetrocyclic compounds containing nitrogen play an important role. It is a focus of the research of novel Pharmaceuticals. But there are a little research on nitrogen-containing benzoheterocyclic compounds: 3,4-dihydro-2(1H) quinoxalinone, 1,2,3,4-tetrahydro-quino-xaline, 2,3-dihydro-l,4-benzo- xazine, and 2,3-dihydrobenzoxazole. In fact, they play an important role in many Pharmaceuticals, perhaps are their bioactivity's center. Therefore they maybe have potential bioactiviry.The pyrimidines or the imidazolines, whose structures are simple, exist in nature wildly. They are vital role in the research and exploitation of Pharmaceuticals. The research on them is hot. Pyrimidine and imidazoline exist in a large number of medicines. Meantime, lots of new compounds containing pyrimidinecycle or Imidazolinecycle own potential bioactivity. So it is sure to say that They have bioactivity.The research of quantitative structure-activity relationships(QSAR), which can predict compound's bioactivity, helps to know the pharmaceutical effect and design target molecular(TM). On the basis of free-wilson model, two kinds of target molecular owning potential bioactiviry are designed, as following:In order to research the synthesis of target molecular, the synthesis of nitrogen-containing benzoheterocyclic compounds has been synthsized firstly. Compared with different synthetic methods and based on the preceding researches in our laboratory, the synthesis method of those nitrogen-containing benzoheterocyclic compounds was optimized. It is simple and direct to prepare from inexpensive and ease materials. Several derivates were prepared successfully on their properties ofsecondary ammonia.Four types of N-chloroacetyl and N, N'-dichloroacetyl substituted nitrogen-Containing intermediate compounds were successfully designed and synthesized. Their were treated with 2-mercapto-4,6-dimethy pyrimidine respectively, they were introduced into pyrimide structure. In same method, reated with 2-mercapto-benzoic-midazoles respectively, they were introduced into imidazoline structure. The structures of all new compounds were identified by MS, high resolution-NMR and elemental analysis.