Asymmetric Reduction Of Carbonyl Groups

The asymmetric reduction of the carbonyl groups is an important methodology, in which the chiral center of the complex compounds can be easily founded, the steps of reactions can be shortened, and the yield can increase.BINAL-H (Binaphthol-Modified Lithium Aluminum Hydride Reagents) was obtained via five steps from racemic binathphol. Two cyclopentanone derivatives were obtained: 2-allylcyclopentanone(I) and 2-methylcyclopentanone(Ⅱ). (Ⅰ) and (Ⅱ) were respectively reduced by BINAL-H to corresponding optically active alcohols: (+)-2-allylcyclopentanol(Ⅳ) and (+)-2-methylcyclopentanol(Ⅴ). And their structures have been identified.