The Study Of The Reaction Of Difluoro Iodoketones And Olefine Acids

Fluorine element, with the largest chemical electronegative, is of many unique chemical properties, which contribute to its important status in the chemical developmental historiography. Throughout the history of the development of the organic fluorine chemistry, the introduction of fluorine atoms into the organic molecules can often improve its solubility, structural stability and biological activity largely. And it is precisely because of these characteristics of fluorine atom, the introduction of difluoromethylene group into the drug molecules also has a great prospect.Meanwhile, many studies have shown that the introduction of the functionalized lactone group plays an important role in the improving of the bioactivity of the drugs. In many natural chemical molecules with biological activity, the functionalized lactone group is the main structure, such as spices, information insect attractant, alkaloids and macrocyclic antibiotics and so on. Therefore, the synthesis of the fluorine-containing lactones has attracted great attention for pharmacologist.Firstly, this thesis synthesized a series of difluoro iodoketones by Claisen ester condensation, Selectfluor fluoride, and trifluoroacetyl release,with the acetophenone compounds as the raw materials. Secondly, under the new radical reaction conditions, we synthesized series of novel structure difluoromethylene-containing y-butyrolactone with the difluoro iodoketones as the raw materials to react with different olefine acids, for which provides new pharmaceutical intermediate compounds for the further synthesis of complex fluorine-containing lactone active molecules.