Chitosan Templated Synthesis Of Silica Porous For Drug Rlesase

Porous silicon membrane material, which is made up of interpenetrating or closed holes, is a kind of network construction materials. It possesses huge utilization potentiality in biochemistry, environment, electrochemical as well as drug delivery and controlled-release technique on account of its controllable aperture distribution, large specific surface area and excellent adsorption and catalytic performance.This paper adopted template method to synthesis porous silicon material. As natural polymer chitosan have many qualities that synthetic polymer surfactants cannot compare with, it is used as the drug delivery carrier material for its favorable biocompatibility, hypotoxicity, and high biodegradability. In this experiment, the chitosan is adopted as the drug delivery template, and TEOS as the silicon source, together with aluminum nitrate nonahydrate, is successfully synthesized into SiO2 nano-composite material. Special specific surface area, porous volum and hole size can be regulated by chitosan content and silica-alumina ratio. The physics and chemical property of drug carrier and the membrane material of drug carrying are scanned under TEM, SEM, N2 BET, and TG to conduct research on representation as well as release behavior in vitro. The result showed that the synthesized chitosan template SiO2 nano-composite material has high specific surface (244～607m2/g), porous volum (0.19-0.34 cm/g) and narrow pore size distribution. SiO2 nano-composite material, as the drug carrier of levofloxacin, is used to research on drug release behavior which shows the initial quick release and succeeding controlled-release, and long-playing antibacterial effect. And the performance depends on existence of porous component and aluminum ion.At last, by taking use of SiO2 nano-composite material and CS/SiO2 compound without aluminum oxide to absorb MB, it shows that SiO2 nano-composite material has high absorption rate.