The Solution Behavior Of Sodium Alginate And Its Derivatives And Its Medicinal Properties

Sargasso resources in hainan are rich.The reseach of the hainan sargasso sodium alginate’s production, performance and application can greatly promote the development of the seaweed industry in China. In this paper, the acid coagulation-acidification method of extraction and purification of hainan sargasso sodium alginate, we study the performance structure; Preparation of the three kinds of molecular weight and cholesterol alginic acid derivatives of return (CSAD), studies its solution behavior; Finally explores the different drug release properties of nanoparticles.The main results were as follows:Using the response surface method to optimize the acid coagulation acidification method to extract the hainan sargasso digestion process of sodium alginate, get the best process conditions for:Na2CO3concentration2.49%, digestion temperature61.42℃, digestion time2.07h. Predict the best extraction rate was34.99%, the measured values is34.99%, the relative error of only0.0477%, the fit of the model is very good; By FTIR, HNMR and GFC analysis shows that the extract product for sodium alginate; The sodium alginate with low molecular weight, molecular weight distribution of uniform; Besides using hydrogen peroxide under acidic conditions by controlling the degradation temperature to get sticky molecular weight were2.7and48000product of sodium alginate.The membrane filtration method and acetone precipitation are used to meet the requirements of chemical pure purified from sodium alginate;Using ｉr,’HNMR analysis found that city purchase sargasso SA SA and hainan M and G period of collating sequence vary widely;The GFC, TEM and fluorescence spectrum analysis method is:for low molecular weight to the hainan sargasso SA, molecular weight distribution is uniform，In aqueous solution of a linear network crosslinking distribution, in0.15mol/LNaCl solution can self-assemble to form uniform dispersion, particle size of the aggregate of roughly40nm, the CAC is0.8847g/L.The three kinds of molecular weight of modified products CSAD was successful prepared;Using pyrene fluorescence probe technology inquiry found that three return molecular weight CSAD micellar system slightly decreases with increasing the concentration of polarity;When solution concentration is greater than the CAC, the decrease of the pH or NaCl ionic strength increases, would lead to increased micelle, micro polarity solution is reduced, and small molecular weight aggregation occurred more often in the aqueous solution, so the change is more obvious;By laser particle size instrument analysis found that the higher solution concentration, the larger the molecular weight, the greater the aggregate particle size;Return different molecular weight CSAD solution aggregate size pH dropped from9to1.41, aggregate size will experience first increases, then decreases and then increases in a series of process;CSAD aggregate diameter with the increase of the concentration of NaCl solution micelle contraction, the particle size decreases, while the smaller molecular weight, micellar contraction is more apparent, particle size decreases faster;Through the determination of zeta potential return found the same molecular weight CSAD solution aggregate surface charge increases with the increase of pH decreases as before, the return of different molecular weight CSAD solution under the same pH value, the aggregate surface increases with the increase of molecular weight and charge;Return the same molecular weight of CSAD solution aggregate surface charge decreases with increasing the concentration of NaCl, return of different molecular weight CSAD solution under the same concentration of NaCl, aggregate surface increases with the increase of molecular weight and charge.The CSAD-CaCl2, CSAD-SiO2, CSAD-cyclodextrin drug-loading nanoparticles in solution were self-assembled into dispersivity observed by TEM. The nanoparticles were uniform and of good dispersivity. The particle size, respectively, in100nm,50nm,500nm;The drug release experiment found that the same nanoparticles coating rate increases with the increase of molecular weight, the same conditions for preparation of nanoparticles, CSAD phase at the same time, the molecular weight of CSAD return-the return of CaCl2, CSAD-cyclodextrin, CSAD-SiO2of drug-loading nanoparticles coating rate, in turn, decreased;The same nanoparticles drug release rate and relatively slow, with the increase of molecular weight equivalent conditions for the preparation of nanoparticles, CSAD phase at the same time, the molecular weight of8hcsad CaCl2,8hcsad SiO2,8hcsad-cyclodextrin slow-release effect of drug-loading nanoparticles is getting better and better.