Synthesis Of Open-knot Via Using Metal Ions Template

Topological knots were presented in many biological macromolecules such as DNA chains and some protein. But synthetic a manual topological molecular knot is still a tremendous challenging research. In the first chapter, we introduced summarization of knot theory and chemical topological overview. And introduce the classification of topology knot and their property. And introduce the development of knot research and recently synthesis instances.The second chapter, we introduces the synthesis of dialdehyde bipyridine ligands with terminal amino bridge compound, And then used the Dialdehyde coordination compound interact with the amino compounds to form a Schiff base to obtain a molecular knot. In addition, at the same time we introduced another bipyridine ligands and 2,6-dialdehyde pyridine, the two pyridine ligands interact to form Schiff base, and then templated by zinc ions to obtain a molecular knot. Due to the two metal templated synthesis of molecular knot did’t succeed, so we design to synthesize two long chain ligands containing three bipyridine ligand (L1 and L2), and this kind of long chain ligands canbe obtained from cyclohexyl-bisphenol compound and bipyridine ligands via Mitusunobu reaction, the ligand can avoided the interaction between the ligands over the coordination process. Finally, the target compounds characterization by 1H NMR, 13C NMR and high resolution mass spectrometry.The third chapter introduces ligands L1 and L2 templated by zinc ions and ferrous ions to form a space open-knot. And study the property and stablility of zinc open-knot and ferrous openknot. At the same time, we designed and synthesized a terminal-azide bridge compounds (L3) in order to get more complicated molecular knot. In the experiment work, we will design a terminal-alkynyl ligand compound to assemble a knot, so that we can through the 1,3-dipolar cycloaddition connected the bridge compounds and open-knot to obtained complex molecular knot, target compounds identify by 1H NMR,13C NMR and MALDI MS spectrometry for structure determination and stabile property test.