Synthetic Methods Of Proline Derivatives And Chalcones

This thesis aims at the studies on confirm synthesis of Proline derivatives and Chalcone Desmethylxanthohumol J. All the compounds were elucidated based on apectroscopic methods like nuclear magnetic resonance.â… :Review of research on Proline derivativesThis chapter recount the importance of chiral molecules, asymmetric reactions, structural classification of proline and proline important reactions in the synthesis of asymmetric molecules.â…¡:Process Synthesis of three proline derivativesThree proline derivatives have been synthesized through reduction reaction, the proctect of PTSC, azide reaction and so on, starting from cheap proline.The key step is to choose what kind of protecting group to protect hydrogen bond. All the compound have been confirmed by NMR.â…¢:Process Synthesis of Desmethylxanthohumol JThe chapter present the synthesis of Desmethylxanthohumol J through intermolecularly and intramolecularly catalized cyclization, protection and deprotection of hydroxyl bond, aldol condensation and son on starting from cheap 2,4,6-Trihydroxyacetophenone.The most important intermediate compound is Isopentenyl cyclization.