Asymmetric Epoxidation Of α,β-Unsatu Rated Enals Catalyzed By Spiro-Pyrrolidine

As epoxides widely exist in bioactive molecules and they are important organic intermediates in organic synthesis, to obtain the high optically active epoxides becomes a target for organic chemists. In this thesis, asymmetric epoxidation of a,β-unsaturated enals were accomplished by using a new type of Spiro-Pyrrolidine, which was developed by our group, with moderate yields, high enatioselectivities and diastereoselectivities (up to 87% yield,>99:1 dr and 99% ee). Although the yield of the reaction is lower than others, we can get more excellent dr and ee values which catalyzed by this type of Spiro-Pyrrolidine in aryl-and alkyl-substitute substrates.