Synthesis Of Chiral α-aryl-β-amino Phosphonates Via Rh Catalyzed Asymmetric Hydrogenation

In this dissertation, a series of bisphospines ligands derives from (anti)-4-hydroxyproline were designed, synthesized and applied to the Rh-catalyzed asymmetric hydrogenation of a-aryl-β-enamidophosphnates. After screened the kinds of the phosphine ligands and optimized other reaction conditions, excellent yield (up to 99%) and excellent enantioselectivity (up to 98%) were achieved when 5% catalyst 4i was applied in this asymmetric hydrogenation. This catalytic system has general substrate accommodation.