| Chapter 1:This chapter briefly introduced the structure, properties, preparation, chemical modification, characterization methods and applications of Fe3O4 magnetic nanoparticles. The preparation and applications of β-cyclodextrin (β-CD) and its derivatives modified Fe3O4 magnetic nanocompounds were reviewed in detail.Chapter 2:Fe3O4 magnetic nanoparticles (MNPs) were prepared according to chemical coprecipitation method. After amination with amino silane coupling agent, magnetic nanoparticles reacted with sulfonyl grafted β-cycledextrin via condensation reaction to synthesize [3-CD modified Fe3O4 magnetic nanocompounds (β-CD-MNPs). The structure, particle size, morphology, magnetic properties of Fe3O4 MNPs and β-CD-MNPs were characterized by Fourier transform infrared spectroscopy, transmission electron microscopy (TEM) and dynamic light scattering, X-ray diffraction, vibrating sample magnetometer and thermogravimetric analysis. The results of infrared spectroscopy and thermogravimetric analysis demonstrated that the β-CD has been modified onto Fe3O4 MNPs successfully,46.32 mg β-CD grafted on per gram Fe3O4 magnetic nanoparticles which calculated by thermogravimetric analysis datas. Fe3O4 MNPs and β-CD-MNPs could be observed dispersed evenly from TEM micrographs, particle size distributed in 12±2 nm, which was consistent with the particles size 14.2 nm that calculated by X-ray diffraction datas. Superparamagnetism of Fe3O4 MNPs and β-CD-MNPs could be observed from the hysteresis loops. Before and after coated by β-CD, saturation magnetization values were 64 emu/g and 48emu/g, respectively.Chapter 3:The loading and release behaviors of β-CD-MNPs as drug carrier were evaluated by fluorescence spectroscopy method using doxorubicin hydrochloride (DOX) and epirubicin hydrochloride (EPI) as model drugs. The effects of pH on P-CD-MNPs for drug loading were investigated, under the optimum pH conditions, the maximum loading quantities of P-CD-MNPs for DOX and EPI were 70.27 mg/g and 39.46 mg/g, loading behavior followed Freundlich adsorption balance equations with multilayer adsorption. Drug-β-CD-MNPs compounds were prepared by ultrasonic method. In vitro release efficiency was higher under acid solution than netural solution, at 37℃. Accumulated release efficiency of DOX and EPI in 6 h were 37.4% and 10.8% at pH=5.Chapter 4:Citric acid grafted β-CD modified water-based magnetic fluid was synthesized via layer-by-layer method. The structure, morphology, composition and magnetic properties of magnetic fluid were characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, thermogravimetric analysis, X-ray diffraction and vibrating sample magnetometer. The results showed that the magnetic nanoparticles of magnetic fluid dispersed well and the diameters were in the range of 7±2 nm. The magnetic fluid was superparamagnetic and magnetic saturation value of magnetic fluid was reduced to 43 emu/g from 62 emu/g after coated by CA-β-CD. The magnetic fluid as an adsorbent was used for neutral red. The effects of reaction time, initial concentration of neutral red and pH on adsorption were studied by fluorescence spectroscopy method. The results showed that in secondary water, magnetic fluid possessed the highest adsorption effect for neutral red, the maximum adsorption capacity was 244 mg/g and the adsorption efficiency was up to 99.8%.Chapter 5:This part summarized the loading behaviour of β-CD-MNPs for guest molecular, drugs and neutral red. The new preparation methods of cyclodextrin modified magnetic nano-compounds would be established and they would be applied in many other fields. |
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