The Click Reaction Synthesis Of Water-soluble Ligand-catalyzed Suzuki And Hiyama Coupling Reaction

The N-containing ligand was designed and synthesized by the simple click reactions, it could be dissloved in water well through grafting the water-solube group. It could get the purpose of the green chemsitry of solution and financial applicability. We used it to catalysis the Suzuki and Hiyama cross-coupling reactions, to check the high efficiency and green chemistry.1. progess in click reaction, Suzuki and Hiyama cross-coupling reactions were summarized in over the years. We studied the origin, development and the application of the click reaction. For the cross-coupling reactions, we discussed the effects of the catalysts, the ligands and the solvents. From the tropism of cross-coupling reactions, we decided the methods we used.2.NaN3 and Phenylactylene was used to systhesis the [1,2,3]-triazole group, then the Cl that was in end of the chain reacted with trimethylamine. They became the big cation group, so the ligand had good water-solubility. So the PdCl2@L could be dissolved in water easily. Because this we choose the water as the solvent.3.In the air condation, in water solution, we used the K2CO3 as the base, the PdCl2@L could catalyze the Suzuki-Miyaura cross-coupling reaction efficiently. The ton of 0.001 mol% PdCl2@L was up to 91000 for both of the electron-withdrawing group and donating group could get high yield, all the reactions of them could been complete in 30 min. for now the research of Hiyama cross-coupling was not so many, so our study of it was very necessary.