Single-particle Microbeam Device Simulation Of Physical Processes And Image System Test Research

Single-Particle Microbeam facility, as a member of variaty ion microbeam has caught increasing interests. An accelerator-based single-ion microbeam have been designed to deliver MeV ions one by one to the specific target such as region of individual living cells with a beam spot within several micrometer which is no more than cell or sub-cell scale.The single-ion microbeam project at Fudan University was stated in 2009, the facility was based on 2×3MV tandem accelerator, and designed to produce a proton or a particle microbeam for cell irradiation.In Chapter 2, beam optics is performed by TRANSPORT/TURTLE and the results show that the optimical design of the beam transportation gives a beam spot at a scale of no more than 2mm in x direction and 3mm in y before it steps into the collimator of the glass capillary for extracting a collimated microbeam, without compromising the beam divergent angle more than mrad, and exclude the potential impact of space-charged effect.In Chapter 3, A Monte Carlo simulation with GEANT4 on the micro-collimator by a borosillicate glass capillary, and the beam qualities analysis are performed with regard to the incident beam parameters, such as beam divergent angle, energy change, alignment angle of collimatorand length of collimator. The result shows the beam pollution may be caused in by secondary electrons produced in the glass capillary and the multi-layer films of vacuum mylar, scintillator and aluminium mirror packed on the microbeam exit when the beam ions are collimated through the collimatorFinally, in Chapter 4, the general principle of the design and work flow of the cell irradiation experiment are presentd.