Chemical Ingredients From Petroleum Ether Of Androsace Umbellata

This product is Primulaceae Androsace umbellata (Lour.) Merr. The whole plant, is one of Androsace genus of medicinal species.Androsace from the Tang and Song dynasties began in the folk has spent nearly a thousand years, Modern to adopt experiment grass is used in the treatment of tonsillitis, sore throat, cure stomatitis, acute conjunctivitis, falling injury, as well as the sore throats and so on, in recent years, found Androsace is crude extracts of medicinal plants and monomer compounds (triterpenoid saponins) have inhibiting tumor, and to prevent pregnancy and antiviral pharmacological effects.Using the scientific method for active components from natural products extraction, separation and chemical structure, thus further development and to determine the safety and efficacy of individual compounds, can further develop reasonable and safe use of drugs and functional foods made of natural products, and will be for the development of high efficiency, low toxicity, safe and cheap comes easily to the drug or functional food provided the scientific basis and theoretical basis. Therefore, this paper adopts the combination of classical and modern methods of this kind of point to Androsace umbellata plants of the chemical composition of the system and in further research.In this paper, The dried Androsace umbellata powder was extracted with90%,85%,80%and73%concentration of alcohol. After removal of the solvent under reduced pressure, the residue was suspended in H2O, and then partitioned sequentially with petroleum ether and EtOAc. Using variety of chromatographic techniques, including normal-phase chromatography, Flash,HPLC and gel (Sephadex LH-20) chromatography method, four compounds were isolated from the petroleum ether fraction. Four structures were identified by IR,1D-NMR,2D-NMR and EI-MS spectroscopic methods, and elucidated as secofriedelic acid (1), secofriedelic acid ester (2), a-amyrin(4)和β-amyrin(4)。...