Studies On The Analysis Of Safety Evaluation Method Applied In Chemical Synthesis Of Pharmaceutical Plants

In modern industrial production, security issues have become the most important business run smoothly and social prerequisite. As modern science and safety production management, adhere to the people-oriented, focusing on prevention and comprehensive management concept for the safety assessment of major industry more and more recognition and support. For safety evaluation plays in safety production technical support jobs are increasingly prominent. How early in the project to build the hazards and risks that may exist after the completion of the project to identify and evaluate an urgent research topic.In this paper, hazard identification, risk analysis beforehand (PHA), risk assessment, fire and explosion index Dow Chemical quantitative analysis, Goldberg (Van den Berg) Leland Illinois (Lannoy) TNT equivalent method for the chemical synthesis of a pharmaceutical project is completed hazardous factors may be identified after the operation, while the risk evaluation of the project after the commissioning of the production process, the presence of fire, the possibility of fire and explosion hazardous area and hazardous area index and tank explosion occurred risk assessment, specifically the project after completion of commissioning a major risk exists, harmful factors are fire, explosion, poisoning and suffocation, chemical burns, minor dangerous and harmful factors against objects, mechanical damage, vehicle damage, collapse, falls, heat burns, electric shock, noise hazards, poison hazards, high temperature hazards.Risk assessment indicates tank area is highly dangerous areas, other areas are in low risk areas. Ethoxy amide methyl benzene refining plant and benzophenone workshop fire, explosion index (F&EI) is128, the exposed area is compensated by20m area around the plant, methanol buried tank if the tank explosion, the will form a strong shock wave, the death radius13.3m, shock overpressure may cause the plant area and near the plant staff and building (structure) building damage thereof. Benzoyl chloride tank explosion if the tank will create a strong shock wave, death radius of15.6m, shock overpressure may cause damage to the plant area and near the plant staff and building (structure) building material. Evaluation of the results of the above analysis for enterprise security management technology provides key data, guide enterprises to take corresponding risk pre-control measures to reduce the risk of the system. The risk of the project to ensure that the post-commissioning within the enterprise can afford, to ensure the project intrinsically safe. The results were also applicable to other pharmaceutical plant and related chemical plant safety evaluation.