Preparation Of One-dimensional Nanostructures On Surface Of Biomedical Titanium And Functional Modification

Biomedical metallic titanium is widely used for artificial joints, artificial bone, dental implants and other vascular materials, because of their workability, good mechanical property, low elasticity modulus, high corrosion resistance and good biocompatibility.However, the biological inert flawed of titanium makes it difficult to bind with surrounding tissues. During the usage period the fibrous tissue would appear causing thrombus and failure of implant. In addition, the potential bacterial infection is another complicate issue in the clinical operation. Comprehensive sterilization and aseptic operation still can’t avoid the frequent occurrence of postoperative infection. The main solution for the clinical operation is to inject antibiotic, which possess antimicrobial specificity, but this will lead to drug-resistant strains of bacteria after a long-term injection.Based on the above issues, we construct a functionalization nano-structure on the surface of titanium using hydrothermal method to increase the roughness of the material and the specific surface area. This nano-structure can provide attachment sites for the follow-up grafting. Hydroxyapatite coating can be deposited on surface of the samples to enhance biological activity throngh biomimetic mineralization in vitro. Silver nano-particles were loaded on titanate nanowires to prepare multi-functional composite implant materials with both good biocompatibility and antibacterial property. Below is the specific work content:1. Preparation of one-dimensional nanostructures on surface of titanium and its growth mechanism research2. Silver-loaded on surface of titanium modified with nanostructures to improve the antibacterial properties 3. Biomineralization and surface properties of titanium modified with nanostructures4. In vitro cell experiment of nanostructure modified samples and Ag nanoparticals modified samplesThe results showed that one-dimensional Titanate nanostructures film with uniform morphology can be prepared by hydrothermal method. Both reaction temperature and sodium hydroxide concentration can affect the surface microstructure of the material. We can get the optimal solution through the experiment:pure titanium react with0.2M NaOH for72h in180℃. Ag nanoparticals can be loaded on the nanostructures using ultraviolet light chemical reduction method and they can homogeneous distributed on the entire surface. With the increase of concentration of silver nitrate solution, the antibacterial effect is better. Hydroxyapatite coating can be deposited on surface of the samples treated by hydrothermal reaction. It can also improve the early cell proliferation and differentiation on the surface of the materials.