The Allylic Oxidation Of Acenaphthene Andβ-Carotene And The Synthesis Of A Series Of Acyl Shydrazone

The allylic oxidation is significant in organic synthesis since the products of allylic oxidation are among the most versatile building blocks for the synthesis of several natural products and pharmaceuticals and are materials and intermediates in synthesis of pharmaceutical, food additives, pesticide, flavor and fragrance and functional material. This paper is on the allylic oxidation of acenaphthene and β-carotene and the process conditions are optimized. Research results are as follows.(1)When acenaphthene:sodium chlorite:TBHP is1:2.5:6, the yield of acenaphthenone which is the product of allylic oxidation of acenaphthene is69%for5h at50℃.(2)When acenaphthene:sodium chlorite:copper iodide is1:3:0.1, the yield of acenaphthenone which is the product of allylic oxidation of acenaphthene is76%for12h at50℃.(3)When β-carotene:sodium periodate:sodium iodide is1:3:0.1, the yield of canthaxanthin which is the product of allylic oxidation of β-carotene is68%for3h at room temperature.The interest in the study of hydrazones has been growing, due to their strong coordination ability, diverse coordination forms, broad spectrum of the biological and pharmaceutical activity and well characters in nonlinear optics. Research results are as follows.(1)Eight acenaphthenone acyl hydrazones were synthesized and characterized by elemental analyses, IR spectra, mass spectra and1HNMR.(2)Eight salicylic aldehyde acyl hydrazones were synthesized and characterized by elemental analyses, IR spectra, mass spectra and1HNMR.