Synthesis, Structures And Properties Of Pyridazine/Pyrimidine-triazole Ligands And Its Complexes

Pyrimidine compounds and pyridazine compounds have got the attention ofpeople, because of their simple structure characteristics and extensive biological acti-vits. Especially, the trace elements of biology are imported in such compounds, suchas Ni、Cr、Co、Zn、Fe、Cu、Mn and so on, which will greatly improve the biologicalactivities of these compounds. In this paper, we selected pyrimidyl and pyridazyl asspacer to synthesize three rigid ligands, and their complexes have been synthesized bysolvent diffusion methods. The main contents of this paper are as follows:Firstly, we have synthesized3-chloro-6-(1H-1,2,4-triazol-1-yl) pyridazine(ditrzpy) and3,6-di(1H-1,2,4-triazol-1-yl) pyridazine (trzpy) by3,6-dichloropyridazine and1H-1,2,4-triazole as reactants. At the same time, we haveobtained five novel complexes: Cu4(ditrzpy)2Br4(1), Cu(trzpy)2Cl2(2),[Co(trzpy)2Cl2(H2O)2]·trzpy (3),[Mn(trzpy)2Cl2(H2O)2]·trzpy (4),Cu(trzpy)2(NO3)2H2O (5), by solvent diffusion methods. The antioxidant activities(influence on O2˙-and˙OH) and antibacterial activities of the ligand and their fivecomplexes were also investigated.Secondly, we have synthesized4,6-di(1H-1,2,4-triazol-1-yl) pyrimidine (ditrzmi)by4,6-dichloro-pyrimidine and1H-1,2,4-triazole as reactants. Then, we have ob-tained three novel complexes:[Zn(ditrzmi)Cl2]n(6),[Cu2(ditrzmi)4(H2O)2ClO4]n·3nClO4(7) and [Cu(ditrzmi)2(NO3)2]n(8), and by evapo-ration of a solution in ethanol. The antioxidant activities (influence on O2˙-and˙OH)and antibacterial activities of the free ligand and its three complexes were also inves-tigated.