The Synthesis Of Chiral Ligands With Pinene As Chiral Source

Chiral compounds has become a focus for researchers, especially in the field ofmedicine and biology. There are many ways to obtain chiral compounds, in whichthe asymmetric organic reaction of chiral compounds is extremelyvaluable.Transition-metal-catalysis is the best, because it can coordinate with manylingands. More attentions were paid to getting chiral olefin ligand and chiral carbeneligand because of their good reactivity and selectivity.In this thesis, we will use transition metal Rh/olefin, carbene ligand to catalyseasymmetric1,4addition reaction. We mainly use convenient and simple pinene aschiral source. After two-step reaction, brominated substituents obtained. They reactwith imidazole compounds to get olefin, carbene ligands, which make ligand familymore rich. We will carry out the Rh-catalyzed1,4addition by the ligands. Studieshave shown that the selectivities of the products are relatively good. Then, wechange the condition of the best results of the lingand. In conclusion, theRh-catalyzed asymmetric addition reaction can get best selectivity under the KOHas alkaline and the temperature is70℃。Although the result of the asymmetric reaction is still some distance from theideal. We can optimization reaction condition and try to the other type of reactionand we believe that these ligands can reach the high selectivity in asymmetricreaction.